Stem Cell Donor Matching for Patients of Mixed Race

Posted in Economics, Health/Medicine/Genetics, New Media, Papers/Presentations on 2010-03-10 02:28Z by Steven

Stem Cell Donor Matching for Patients of Mixed Race

2011-04-04
21 pages

Ted Bergstrom, Aaron and Cherie Raznick Chair of Economics
University of California, Santa Barbara

Rod Garratt, Professor of Econommics
University of California, Santa Barbara

Damien Sheehan-Connor, Assistant Professor of Economics
Wesleyan University

The plight of multiracial leukemia patients who are unable to find matching stem cell donors has received much media attention. These news stories, while dramatic, are short on statistical information and long on misconceptions. We apply simple probability theory, the genetics of sexual diploid reproduction, and the theory of public goods to produce estimates of the probabilities that multiracial patients will find matching donors in the existing registry. We then compute the benefits and costs of registering more potential donors of single and mixed races.

…4.1 The concept of race

The racial categories, white, African-American, Asian-American, and Hispanic into which NMDP registrants are sorted is coarse and somewhat arbitrary. Since the recorded race of a registrant is self-declared, it indicates a social construction that does not necessarily correspond to genetic inheritance. Statistics show, however that the distribution of HLA types differs markedly between races.  For example, the probability that a randomly selected white American will match another randomly selected white is 34 times that of matching a random Asian-American, 16 times that of matching a random African-American, and 6 times that of matching a random Hispanic. These distributional differences have important implications for recruitment of registrants from racial minorities.

Our statistical measurements are built on the Kollman et al [11] estimates of haploid distributions within each race. Kollman’s estimates, like those in the earlier study by Mori et al [13], are founded on a model that makes two critical assumptions about marriage patterns.  The first assumption is that each racial group is endogamous, that is marriage occurs almost entirely within races. The second assumption is that conditional on marrying within group, the probability that two people marry is independent of their HLA types.

Since the social construct of race is more likely to influence marriage patterns than genetic classification, the use of self-declared race to determine categories seems appropriate for the model that is being estimated. Jacobs and Labov [6] collected data on all married heads of households and their spouses from a 1 percent sample of the 1990 U.S. Census. They determined the self-declared race or national origin of each member of each couple. They found that almost 98 percent of marriages of whites and 96 percent of marriages of African-Americans were endogamous. The Jacobs-Labov study shows that approximately 85 percent of Asian-Americans are married to other Asian-Americans and 77 percent of Hispanics are married to other Hispanics.67  The genetic composition of the current population depends, of course, on the marriage patterns of their parents’ generation, not on current marriage patterns. There is good reason to believe that the current population of Asian-Americans and of Hispanics are children of more endogamous populations than is indicated by current marriages. About 2/3 of the existing population of Asian-Americans were born in Asia and their ancestors for many generations would have had little exposure to non-Asians. About 1/3 of the existing population of Hispanics are immigrants from regions where the population is almost entirely Hispanic…

…A similar diffculty is found with “Hispanic” as a racial category. The Hispanic population of the United States includes significant subpopulations that differ in ethnic makeup and have had little contact with each other for many generations. About 66 percent of the Hispanic population of the United States is of Mexican extraction, 13 percent come from Central and South America, 9 percent are Puerto Rican, and 4 percent are of Cuban extraction. Genetic admixture studies of Hispanics in the U.S. reveal that Mexican-Americans on average have 30-40 percent Native American ancestry, while immigrants from the Spanish Caribbean have African genetic contributions that range from 20-40 percent and contributions of about 18 percent from the native American Arawaks and Caribs

…Although current rates of intermarriage between African-Americans and whites are low, African-Americans carry a significant amount of genetic material obtained from white ancestors. As Kittles et al [8] observes, “The vast majority of contemporary African Americans are descendants of enslaved Africans kidnapped and transported to America during the transatlantic slave trade from 1619 to 1850.” During the period of slavery, there was substantial mixing of the white and African-American gene pool. Kittles et al reports that it is estimated that in 1860, “there were 4.5 million people of African descent in the U.S., of which 600,000 were of mixed ancestry or “mulattos”.

Geneticists have developed methods for using genetic markers to estimate admixture proportions, that is the proportions of genetic material in a single population that is inherited from members of two or more distinct ancestral populations. Several studies have estimated admixture proportions from samples of African-Americans. These studies indicate that the percentage of European admixture in the African-American population differs substantially by region, ranging from 3.5 percent in the Gullah sea island community of South Carolina, 10 percent in the rural South, about 20 percent in the industrial North, and 22-35 percent on the West Coast. [8](Figure 2), [14] The admixture of African-American genetic material in the U.S. white population appears to be much smaller. The geographic differences in the genetic makeup of the African-American population suggests that the accuracy of estimations of HLA-distributions for African Americans could be improved by disaggregating according to region of birth…

Read the entire paper here.

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Malaga Island: A Brief History

Posted in Anthropology, History, Media Archive, Papers/Presentations, Social Science, United States on 2010-03-06 19:50Z by Steven

Malaga Island: A Brief History

Compiled by the Students of ES 203 Service Learning Project
Bowdoin College
2003

Adrienne Heflich

Anna Troyansky

Samantha Farrell

Malaga Island is located in Casco Bay, near the mouth of the New Meadows River, and is roughly a half-mile long by a quarter-mile wide in size. It sits approximately one hundred yards from the mainland of Phippsburg. Malaga Island, which means “cedar” in the Abnaki Indian language, is heavily wooded, and has been uninhabited since 1912. The island is rich in archaeological deposits from its past residents. Remains from the pre-colonial Indian and Malagaite mixed-race settlements are largely unexcavated and are believed to be remarkably intact. Currently local fishermen use the island for lobster-trap storage.

Malaga Island was a very unique community. The black and mixed-race population of individuals and families was an anomaly in a state over 99% white. The concentration of minorities in the Malaga Island community caused fear and uneasiness in neighboring white communities on the mainland. Drifters and outsiders of mainland communities, both black and white, settled there in the mid-1800s. By 1900 the population had peaked at 42 individuals and interracial marriages were common on the island. Save for its racial diversity, Malaga resembled most other poor fishing communities on the Maine coast.

The Malagaites’ main source of income was subsistence fishing and limited farming. Tensions rose over issues of resource use as the Malagaites’ fishing directly competed with the economy on the mainland. More importantly, their dark skin, questionable morals, and apparent idleness (all thoroughly exaggerated in biased local and regional press) aroused suspicion and antipathy. In efforts to address the Malaga “problem”, in 1903 a missionary family established an informal school on Malaga in attempts to “reform” the inhabitants. The school was funded at first by private donations, and subsequently subsidized by state funding.

Tensions between the mainland and the island rose significantly at the turn of the century along with the burgeoning tourism industry on the Maine coast; Malaga was an eyesore for the mainland. Harpswell and Phippsburg disavowed jurisdiction over the community and the island was identified as “No Man’s Land,” becoming a ward of the state. In 1912, Governor Plaisted evicted the community of Malaga from their land and homes. Resettlement was prohibited and many Malagaites lacking the means to move elsewhere, were displaced to the Maine School for the Feeble-Minded in Pineland. Some Malagaites strapped their houses to rafts and drifted up and down the river in search of a safe port. However, they were unwanted and stigmatized by the events of 1912. Private owners eventually bought the island, and possession shifted hands numerous times before it was finally acquired by MCHT.

The diaspora of the Malagaites remains a dark chapter in Maine and local history.  Descendents still bear the stigma of their infamous ancestors. An unspoken code of silence still remains, perhaps out of shame, perhaps out of ignorance. Myth still surrounds the factual events. It is hoped that in the near future, the Malagaite and precolonial Indian archeological remains will be excavated, undoubtedly unearthing a very fascinating history.

Read the entire paper here.

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“There’s No One as Irish as Barack O’Bama”: The Policy and Politics of American Multiracialism

Posted in Census/Demographics, New Media, Papers/Presentations, Politics/Public Policy, Social Science, United States on 2010-03-04 04:16Z by Steven

“There’s No One as Irish as Barack O’Bama”: The Policy and Politics of American Multiracialism

Weatherhead Center for International Affairs
Harvard University
February 2010
Working Paper
68 pages

Jennifer Hochschild, Henry LaBarre Jayne Professor of Government and Professor of African and African American Studies
Harvard University

Vesla Weaver, Assistant Professor
The Woodrow Wilson Department of Politics
University of Virginia

Forthcoming publication in Perspectives on Politics, June 2010.

For the first time in American history, the United States’ 2000 census allowed individuals to choose more than one race. That new policy sets up our exploration of whether and how multiracialism is entering Americans’ understanding and practice of race. By analyzing briefly earlier cases of racial construction, we uncover three factors important to understanding if and how intensely a feedback effect for racial classification will be generated. Using this framework, we find that multiracialism has been institutionalized in the federal government, and is moving toward institutionalization in the private sector and other governmental units. In addition, the small proportion of Americans who now define themselves as multiracial is growing absolutely and relatively, and evidence suggests a continued rise. Increasing multiracial identification is made more likely by racial mixture’s growing prominence in American society – demographically, culturally, economically, and psychologically. However, the politics side of the feedback loop is complicated by the fact that identification is not identity. Traditional racial or ethnic loyalties and understandings remain strong, including among potential multiracial identifiers. Therefore, if mixed race identification is to evolve into a multiracial identity, it may not be at the expense of existing group consciousness. Instead, we expect mixed race identity to be contextual, fluid, and additive, so that it can be layered onto rather than substituted for traditional monoracial commitments. If the multiracial movement successfully challenges the longstanding understanding and practice of “one drop of blood” racial groups, it has the potential to change much of the politics and policy of American race relations.

O’Leary, O’Riley, O’Hare, and O’Hara
There’s no one as Irish as Barack O’Bama.
His mam’s daddy’s grandaddy was one Fulmuth Kearney
He’s as Irish as any from the lakes of Killarney
His mam’s from a long line of great Irish mamas;
There’s no one as Irish as Barack O’Bama.

–“There’s No One as Irish as Barack O’Bama“, Hardy Drew and the Nancy Boys (Corrigan Brothers)

Read the entire paper here.

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Mixed Race in the Age of Obama

Posted in History, Identity Development/Psychology, Live Events, New Media, Papers/Presentations, Politics/Public Policy, United States on 2010-02-20 16:04Z by Steven

Mixed Race in the Age of Obama

University of Chicago
Center for the Study of Race, Politics and Culture (CSRPC)
International House, Home Room
1414 East 59th Street, Chicago, IL
2010-03-05, 09:00 to 18:00 CST (Local Time)

The Center for the Study of Race, Politics and Culture at the University of  Chicago presents a daylong conference, “Mixed-Race in the Age of Obama,” which seeks to intervene in the discursive, material, and ideological debates involving mixed-race people nationally and internationally, examining historical, sociological, literary, legal, and other (inter)disciplinary representations of the lived experience of mixed race people. Organized by Dr. Matthews Briones, Department of History at U of C. Co-sponsored by International House Global Voices Program. Free & open to the public.

For more information, click here.

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Theatrical Medicine: Aboriginal performance, ritual and commemoration

Posted in Articles, Arts, Canada, Health/Medicine/Genetics, Media Archive, Papers/Presentations on 2010-02-15 02:43Z by Steven

Theatrical Medicine: Aboriginal performance, ritual and commemoration

The Medicine Project
2008-03-25

Michelle La Flamme

Dr. Michelle La Flamme is an Afro-NDN performer, activist and educator who completed a Ph.D. at UBC [University of British Columbia] in English literature (May 2006). In her other life, she is an avid performer and has worked in film and video production. She tries her best to bridge the world of academia and her creative life and she is often asked to speak or perform at Canadian conferences addressing representations of race in contemporary Canadian art and literature. She was born and raised here on the “best Coast” and has had the good fortune of taking her ideas abroad as a guest lecturer in Germany, Spain and The Netherlands. These days she is particularly interested in Native/Black issues as her bloodlines encompass both sides of the 49th and include Métis, Creek and African-American strains. Currently, she teaches Canadian literature, Academic Writing, Introduction to Fiction and Introduction to Poetry at UBC. She makes the time to write, perform and be involved in community activism when she has the energy.

There are many different definitions of Medicine. As a woman of mixed heritage (Métis, African-Canadian and Creek) I have been exposed to many Aboriginal teachings and ceremonies. My own definition of medicine is based on the teachings of traditional elders who have shared their cultural insight with me regarding the power and meaning of medicine. There are Medicine Wheel ceremonies that involve respect for the four directions and the balance between the physical, mental, spiritual and emotional aspects of an individual. Medicine can be understood in a psychological or philosophical way whereby individuals go through a form of catharsis when they are guided by the teachings. There is medicine involved in seeking advice from elders by way of offering them tobacco. There is participatory medicine involved in being a witness or participant in talking circles, and there is medicine that is physical in the form of tobacco, sweet grass, sage and cedar. There is medicine in ceremony whether these be sweat lodge ceremonies, moon lodge ceremonies, naming ceremonies or longhouse ceremonies. There is medicine in the practice of creating art whether that be carving, weaving or painting. Some traditional languages do not have a word for theatrical performance, so they use the closest word, which is ceremony. These cultural beliefs about medicine and practices which are referred to as medicinal reflect a belief in the power of performance and the possibility of the performance being medicinal for any and all of these cultural associations with medicine. The performances and plays that I examine in this essay can be understood as medicine in that they bring balance to the witnesses through honouring the deceased by way of naming rituals, they bring balance to communities by showing the humanity of Aboriginal women and they provide a cathartic ritual or ceremony for the release of trauma…

Read the entire article here.

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Mixed Messages [Theatrical Play]

Posted in Arts, Media Archive, Papers/Presentations on 2010-02-14 19:38Z by Steven

Mixed Messages [Theatrical Play]

Written by
Michelle La Flamme
University of British Columbia

with help from

Minelle Mahtani, Associate Professor of Geography and Planning
University of Toronto

Burcu Ozdemir

Mixed Messages is a satirical look at the exclusive rules for membership in academic spaces and a jab at racial identity politics in the “mixed race” movement. It was first  performed as part of the monthly Transculturalisms series at UBC, Fall 2002.

Read the script here.

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Language and the Politics of Ethnicity in the Caribbean

Posted in Anthropology, Caribbean/Latin America, History, Media Archive, Papers/Presentations, Social Science on 2010-02-14 05:26Z by Steven

Language and the Politics of Ethnicity in the Caribbean

Center for Research on Latin America and the Caribbean
York University, Toronto, Ontario
The Fourth Annual Jagan Lecture
Presented at York University on 2002-03-02

George Lamming, Visiting Professor
Brown University

The Jagan Lectures commemorate the life and vision of the late Dr. Cheddi Jagan, Caribbean thinker, politician, and political visionary. The series of annual lectures is founded upon the idea that the many and varied dimensions of Cheddi Jagan’s belief in the possibility of a New Global Human Order should be publicly ac-knowledged as part of his permanent legacy to the world.

This lecture was given by the renowned Caribbean writer and intellect George Lamming as part of the Jagan Lecture Series commemorating the late Dr. Cheddi Jagan. Lamming looks at the problem of ethnicity – and especially of relations between Africans and Indians in the territories where they form almost equal populations, namely Guyana and Trinidad – from multiple perspectives. He re-calls dramatizing strategies employed by the old colonial power in this region, strategies that are still used today by contemporary politicians. He proposes that race and ethnicity are socially constructed categories, and draws upon many Barbadian examples to illustrate the absurdity of racial prejudice in a Caribbean context where cultural miscegenation is so deep, and where habits of perception, accents, and tastes are so mixed, that wearing several categories of identity at once is common to all. His conclusion, however, is far from being a curse: the challenges of cultural, linguistic and ra-cial/ethnic diversity faced by the Caribbean constitute part of the wealth of the region, as amply demonstrated by its cultural workers, and its distinct traditions and peoples.

Read the entire paper here.

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Legal Transplants: Slavery and the Civil Law in Louisiana

Posted in History, Law, Louisiana, New Media, Papers/Presentations, Slavery, United States on 2010-02-12 02:47Z by Steven

Legal Transplants: Slavery and the Civil Law in Louisiana

University of Southern California Legal Studies Working Paper Series
Working Paper 32
May 2009
37 pages

Ariela J. Gross, Professor of Law and History
University of Southern California Law School

Can Louisiana tell us something about civil law vs. common law regimes of slavery? What can the Louisiana experience tell us about a civil law jurisdiction “transplanted” in a common-law country? Louisiana is unique among American states in having been governed first by France, then by Spain, before becoming a U.S. territory and state in the nineteenth century. Unlike other slave states, it operated under a civil code, first the Digest of 1808, and then the Code of 1825. With regard to the regulation of slaves, these codes also incorporated a “Black Code,” first adopted in 1806, which owed a great deal to both French and Spanish law. Comparisons of Louisiana with other slave states tend to emphasize the uniqueness of New Orleans’ three-tier caste system, with a significant population of gens de couleur libre (free people of color), and the ameliorative influence of Spanish law. This reflects more general assumptions about comparative race and slavery in the Americas, based on the work of Frank Tannenbaum and other historians of an earlier generation, who drew sharp contrasts between slavery in British and Spanish America. How does the comparison shift if we turn our attention away from slave codes, where Tannenbaum focused, to the “law in action”? At the local level, one can see the way slaves took advantage of the gap between rules and enforcement, and to fathom racial meanings at the level of day-to-day interactions rather than comparisions of formal rules. This essay surveys three areas of law involving slaves – manumission, racial identity, and “redhibition” (breach of warranty) – to compare Louisiana to other jurisdictions, and particularly to its common-law neighbors.

…The first major slave codes in the North American colonies date to 1680-82. They draw numerous distinctions on the basis of race rather than status, including laws against carrying arms and against leaving the owner’s plantations without a certificate. A penalty of thirty lashes met “any Negro” who “lift up his hand against any Christian.” In 1691, English women were fined for having a bastard child with a negro. In 1705, all mulatto children were made servants to the age of 31 in Virginia; Maryland and North Carolina adopted the same rule within the next several decades.

By the time the U.S. became a republic, only those of African descent were slaves, and all whites were free. Yet there were a significant number of individuals and entire communities of mixed ancestry with ambiguous racial identity along the Eastern seaboard. In the southeast, Indian tribes both absorbed runaway slaves and, in the late eighteenth century, adopted African slavery. In addition to the 12,000 people designated in the Census as “free people of color” in Virginia, there were 8000 in Maryland in 1790, 5000 in North Carolina, 1800 in South Carolina, and 400 in Georgia…

Read the entire paper here.

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African Americans and National Identities in Central America

Posted in Anthropology, Caribbean/Latin America, History, Media Archive, Papers/Presentations, Social Science on 2010-02-10 21:41Z by Steven

African Americans and National Identities in Central America

Rina Cáceres, Professor of Diaspora Studies Program at the Centro de Investigationes Historicas de America Central
Universidad de Costa Rica

Lowell Gudmundson, Professor of Latin American Studies and History
Mount Holyoke University

Mauricio Meléndez

An interdisciplinary, multinational research program to reconceptualize and document, both visually and textually, the history of people of African descent in Central America.

Supported by the National Endowment for the Humanities Collaborative Research Program, Mount Holyoke College and The Center for Central American Historical Research at the Universidad de Costa Rica.

Our collaborative research project seeks to reassess the historical presence and contributions of peoples of African descent to the national histories and identities constructed in Central America over the past two centuries. In choosing a color for the cosmic race, modern nationalist thinkers in the region systematically emphasized the European and Indigenous origins of its peoples, in terms of both historical fact and group agency. Thus they radically discounted not only the importance, role, and presence of any African heritage but also as the centrality of racial or ethnic conflict within the historical experience of non-indigenous sectors of society…

Visit the project website here.

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Racial Boundary Formation at the Dawn of Jim Crow: The Determinants and Effects of Black/Mulatto Occupational Differences in the United States, 1880 (Working Paper)

Posted in History, Media Archive, Papers/Presentations, Social Science, United States on 2010-02-10 02:34Z by Steven

Racial Boundary Formation at the Dawn of Jim Crow: The Determinants and Effects of Black/Mulatto Occupational Differences in the United States, 1880 (Working Paper)

33 pages
Updated 2008-07-03

Aaron Gullickson, Assistant Professor of Sociology
University of Oregon

Much of the literature within sociology regarding mixed-race populations focuses on contemporary issues and dynamics, often overlooking a larger historical literature.  This article provides a historical perspective on these issues by exploiting regional variation in the United States in the degree of occupational differentiation between blacks and mulattoes in the 1880 Census, during a transitionary period from slavery to freedom.  The analysis reveals that the role of the mixed-race category as either a “buffer class” or a status threat depended upon the class composition of the white population.  Black/mulatto occupational differentiation was greatest in areas where whites had a high level of occupational prestige and thus little to fear from an elevated mulatto group. Furthermore, the effect of black/mulatto occupational differentiation on lynching varied by the occupational status of whites. In areas where whites were of relatively low status, black/mulatto differentiation increased the risk of lynching, while in areas where whites were of relatively high status, black/mulatto differentiation decreased the risk of lynching.

Read the entire paper here.

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