Mixed Race Studies

Playing the Gene Card? A Report on Race and Human Biotechnology

Center for Genetics and Society
2009
95 pages

Osagie K. Obasogie, Associate Professor of Law
University of California, San Francisco
Also: Senior Fellow
Center for Genetics and Society

Preface by:

Dorothy Roberts, George A. Weiss University Professor of Law and Sociology; Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights
University of Pennsylvania

Executive Summary

Race has become a prominent focus for human biotechnology. Despite often good intentions, genetic technologies are being applied in a manner that may provide new justification for thinking about racial difference and racial disparities in biological terms—as if social categories of race reflect natural or inherent group differences.

The Human Genome Project (HGP) and subsequent research showed that there is less than 1% genetic variation among all humans. Patterns of mating and geographic isolation over thousands of years have conferred genetic signatures to certain populations. Yet scientists have found little evidence to support lay understandings that social categories of race reflect discrete groups of human difference. While HGP findings initially led many to conclude that race (as it is commonly conceived and used) is not genetically significant, the hope that science would promote racial healing has largely not materialized.

In fact, trends in life science research have shifted the other way. There are increasing efforts to demonstrate the genetic relevance of race by mapping this less than 1% of variation onto social categories of race to find genetic explanations for racial disparities and differences.

From page 21

Figure 2: The essentialist and population concepts of race contrasted with the actual patterns of genetic variation (simplified to three geographic categories). Based on the work of Dr. Jeffrey Long at the University of Michigan and depictions created by the Race—Are We So Different? project of the American Anthropological Association.

A Essentialist concepts of race that were popular throughout the 19th and early 20th century held that the human species was divided into several mutually exclusive yet tangentially overlapping groups based largely upon physical features such as skin color and facial features.

B Population approaches treat race as clusters of local populations that differ genetically from one another, whereby each group is considered a race. As depicted, this concept suggests an outer periphery of unshared distinctiveness as well as substantial genetic similarity that is highlighted by the overlapping regions.

C Contemporary data on human diversity supports a “nested subset” approach to race. This reflects the fact that “people have lived in Africa far longer than anywhere else, which has allowed the population in Africa to accumulate more of the small mutations that make up [human] genetic variation. Because only a part of the African population migrated out of Africa, only part of Africa’s genetic variation moved with them. For this reason, most genetic variation found in people living outside Africa is a subset of that found among Africans.”

Many celebrate these developments as an opportunity to learn more about who we are and why certain groups are sicker than others. Yet some are struck by the extent to which these new conversations aimed at benefiting minority communities communities echo past discussions in which the science of biological difference was used to justify racial hierarchies.

Although this new research is rapidly evolving and is fraught with controversy, it is being used to develop several commercial and forensic applications that may give new credence to biological understandings of racial difference—often with more certainty than is supported by the available evidence. This unrestrained rush to market race-specific applications and to use DNA technologies in law enforcement can have significant implications for racial minorities:

• Race-based medicines have been promoted as a way to reduce inequities in healthcare and health outcomes. Yet the methodological assumptions behind them raise as many issues as the questionable market incentives leading to their development.
• Genetic ancestry tests rely on incomplete scientific methods that may lead to overstated claims. The companies that sell them often suggest that biotechnology can authoritatively tell us who we are and where we come from.
• DNA forensics have been used to exonerate those who have been wrongly convicted and can provide important tools for law enforcement. However, some forensic applications of genetic technologies might undermine civil rights—especially in minority communities.

While each of these applications has been examined individually, this report looks at them together to highlight a fundamental concern: that commercial incentives and other pressures may distort or oversimplify the complex and discordant relationship between race, population, and genes. Applications based on such distortions or oversimplifications may give undue legitimacy to the idea that social categories of race reflect discrete biological differences.

The concerns raised in this report should not be read as impugning all genetic research that implicates social categories of race. There is evidence that socially constructed notions of race may loosely reflect patterns of genetic variation created by evolutionary forces, and that knowledge about them may ultimately serve important social or medical goals. Yet, given our unfortunate history of linking biological understandings of racial difference to notions of racial superiority and inferiority, it would be unwise to ignore the possibility that 21st century technologies may be used to revive long discredited 19th century theories of race.

Advances in human biotechnology hold great promise. But if they are to benefit all of us, closer attention should be paid to the social risks they entail and their particular impacts on minority communities.

Contents

• Executive Summary
• About the Author
• Acknowledgments
• Preface by Dorothy Roberts, Kirkland & Ellis Professor of Law, Northwestern Law School
• Race Cards and Gene Cards: A Note About the Report’s Title
• Introduction | Are 21st Century Technologies Reviving 19th Century
  • Theories of Race?
  • How Have New Genetic Theories of Racial Difference Developed?
  • Context: After the Human Genome Project
  • Key Concern: Will Commercial and Forensic Applications Revive Biological Theories of Race?
  • In This Report
  • Sidebar: What Does It Mean to Say that Race Is Not Biologically Significant or that It Is a Social Construction?
• Chapter 1 | Race-Based Medicine: One Step Forward, Two Steps Back?
  • Pharmacogenomics: The Concept Behind Race-Based Medicine
  • First on the Scene: BiDil
  • Concerns about BiDil
  • Addressing Disparities in Health Through Race-Specific Pharmaceuticals
  • Conclusion: Evaluating Race-Based Medicine
  • Recommendations
  • Sidebars: Major Projects on Human Genetic Variation
    • Why Genetic Variations Matter
    • Top-Down Marketing to the Black Community
    • Historical Theories of Race
    • Are More Race-Based Medicines Around the Corner?
    • The Slavery Hypothesis
• Chapter 2 | Ancestry Tests: Back to the Future?
  • African American Ancestry
  • Context: Population Genetics
  • From Groups and Populations to Individuals
  • Techniques Used by Ancestry Tests
  • Concerns about the Genetic Ancestry Industry
  • Conclusion: Resisting Racial Typologies
  • Recommendations 30
  • Sidebars: Native Americans and Ancestry Tests
    • Race, Intelligence, and James Watson
    • Bioprospecting and Biopiracy
    • From Race to Population and Back
    • The Business of DNA Ancestry Testing
    • Special Types of DNA
    • Human Genetic Variation—A Work in Progress
• Chapter 3 | Race and DNA Forensics in the Criminal Justice System
  • How Does It Work?
  • How Reliable Are DNA Forensic Technologies?
  • DNA Databases
  • Cold Hits and Partial Matches
  • Whose DNA Is in These Databases?
  • Sifting DNA Databases to Catch Family Members
  • Predicting Criminality
  • Using DNA to Build Racial Profiles
  • Conclusion: Effects on Minority Communities
  • Recommendations
  • Sidebars: DNA Entrapment?
    • The Scandal in Houston
    • The Innocence Project
    • “The Informer in Your Blood”
    • Juking Stats
    • “The Birthday Problem” and the Limits of Forensic Database Matches
    • Minority Communities and the War on Drugs
    • Civil Liberties and DNA Databases
    • Phrenology, a Classic Pseudo-Science
• Conclusion
  • Racial Categories in Human Biotechnology Research
  • Race Impact Assessments
  • Responsible Regulation
• Endnotes
• About the Center for Genetics and Society

Read the entire report here.

CUNY DSI Monograph Documents Dominican Heritage of First Settler

The City University of New York
City College
2012-10-04

Juan Rodríguez, native of Santo Domingo, comes to New York in 1613 and stays when his ship sails to Holland

The first non-native to live in what is now New York City was a black or mixed race Dominican, a new monograph produced by researchers at the CUNY Dominican Studies Institute (CUNY DSI) documents. Juan Rodríguez, who was born on the colony of La Española, now the Dominican Republic, came to the Big Apple in 1613 aboard a Dutch trading vessel en route from the Caribbean. He decided to stay and live among the natives when the ship returned to Holland.
 
“This is the kind of research that produces new academic knowledge and engages in a conversation with a scholarly community who studies New York City’s early history,” said Dr. Ramona Hernández, director of CUNY DSI. “This research also serves people from a practical point of view: A very early predecessor of the large Dominican population that thrives in New York City today, Juan Rodriguez’s story belongs to the history of all New Yorkers.
 
“As residents of a port city with a uniquely multiethnic population since its very beginnings next to the mighty Hudson River, New York has always been a community of interactions and intermingling amongst races and ethnicities.”
 
The monograph was commissioned by the American Chamber of Commerce of the Dominican Republic, which will receive the first copy at a luncheon meeting at City College Thursday, October 4. The following day, a two-hour colloquium with experts in translations and transcription will examine the challenges, excitement and insights of translating the documentation for the Juan Rodríguez story.
 
Earlier this week, New York City Mayor Michael Bloomberg named a stretch of Broadway between W. 159th Street and W. 218th Street for Mr. Rodríguez. The section of the famed roadway runs through Washington Heights, home of one of the largest concentrations of Dominicans living outside their homeland.
 
According to archival records reviewed by DSI researchers, Mr. Rodríguez, a black or mulatto free sailor born on La Española, arrived in an estuary of the Hudson River in the spring of 1613, aboard the “Jonge Tobias,” a Dutch ship captained by Thijs Mossel. After two months presumably spent trading with Native Americans, Captain Mossel decided to return to Holland, but Mr. Rodríguez refused to make the journey and was allowed to stay on shore…

Read the entire article here.

Race-Based Medicine: Déjà Vu All Over Again?

Biopolitical Times: The weblog of the Center for Genetics and Society
2012-09-18

Osagie K. Obasogie, Associate Professor of Law
University of California, San Francisco
Also: Senior Fellow
Center for Genetics and Society

Race-based medicine has been one of the more contentious issues in pharmaceutical research and development over the past few years. Some argue that drugs specifically labeled to treat particular racial groups offer an invaluable way to fight racial disparities in health by targeting at-risk populations. Others claim that race-based medicine inappropriately treats race as a biological cause of racial disparities when broader social and environmental factors may offer better explanations.

Much of this debate involves the FDA’s 2005 approval of BiDil, which became the first drug to be labeled for a specific racial group – African Americans with heart failure. The heat generated from this debate has largely faded due to BiDIl’s market failure.  But, it seems like a new drug may reignite a few flames.

Tradjenta was developed by Boehringer Ingelheim Pharmaceuticals and Eli Lilly to treat Type 2 diabetes. But results from a Phase III clinical trial recently showed that Tradjenta was particularly beneficial for controlling African Americans’ blood sugar levels…

…Is another BiDil on the horizon? It’s important to acknowledge that Tradjenta had already received FDA approval to treat type 2 diabetes in the general population prior to the announcement of these race-specific results. This is different from BiDil, where investigators sought a race-specific indication from the FDA because they could not otherwise win regulatory approval as a race-neutral drug. Despite these differences, treating racial disparities in diabetes as a naturally observed group difference that can be at least partially resolved with a pill shares some similarities with the BiDil saga. In both cases, there is a tendency to naturalize racial disparities as a function of group difference rather than having a deeper engagement with the social determinants of health.

This leads to an important question: if Tradjenta already received approval for use in the general population, why would it not be effective in African Americans? Put differently, why go through the time and expense of conducting a clinical trial to demonstrate efficacy in a particular racial group when the drug has already been approved for everyone regardless of race?

It’s unclear how these recent clinical trial results might be used. Perhaps this is another example of using a clinical trial as a marketing device in the hopes of capturing a larger share of the market…

Read the entire article here.

Deep Roots and Tangled Branches

The Chronicle of Higher Education
2006-02-03

Troy Duster, Chancellor’s Professor of Sociology
University of California, Berkeley
Also Professor of Sociology and Director of the Institute for the History of the Production of Knowledge
New York University

People who know their biological parents and grandparents typically take the information for granted. Some have a difficult time empathizing with the passionate genealogical quests of adoptees and, increasingly, products of anonymous sperm banks and other new technologies where one or both genetic contributors are unknown. In recent years, new legislation has enabled people to search for information about genetic progenitors – even in cases where there had been a signed agreement of nondisclosure. The laserlike focus of that search can be as relentless as Ahab’s hunt for the white whale.

Mystery of lineage is the stuff of great literature. Mark Twain made use of it for biting social commentary in his Pudd’nhead Wilson, a story about the mix-up of babies born to a slave and a free person. Sophocles, Shakespeare, Molière, and Dickens built grand tragedy and enduring comedy on the theme. In England in 2002, a white Englishwoman gave birth to mixed-race twins after a mix-up at an in vitro fertilization clinic. Imagine what Shakespeare would have done with that!

If one person’s passions can be so riled by such a puzzle, imagine the emotions involved when the uncertainty applies to a whole group – say, of 12 million people. The middle passage did just that to Americans of recent African descent. Names were obliterated from record books, and slaves were typically anointed with a new single first name. Sometimes no names were recorded, just the slaves’ numbers, ages, and genders. Some African-Americans have deliberately and actively participated in the erasure, showing no desire to pursue a genealogical trail. For others, fragments of oral history generate a fierce longing to do the detective work.

That is the case among the prominent subjects featured in “African American Lives,” a two-night, four-part PBS series scheduled for February 1 and 8. The host and executive co-producer is Henry Louis Gates Jr., chairman of the department of African and African-American studies at Harvard. Gates has assembled eight notably successful African-Americans, among them the media entrepreneur Oprah Winfrey, the legendary music producer Quincy Jones, and the film star Whoopi Goldberg. Each participant, along with Gates, is the subject of some serious professional family-tree tracing. There are surprises for each of them, and the series has undeniable human-interest appeal…

Read the entire article here.

Racial Labels Have Limited Use In Personalizing Medicine

Shots: NPR’s Health Blog
2011-05-09

Eliza Barclay

For all the fanfare around personalized medicine, the idea has been fairly slow to take off.

Boosters have said if doctors had a patient’s DNA information it would be revolutionary: They could look for genetic risk of certain diseases or mutations that determine whether certain drugs are likely to work or not.

The cost of DNA sequencing keeps falling, yet genetic sequencing for medical use isn’t commonplace. In the meantime, doctors can, in theory, consider a patient’s race in anticipating health conditions that could pose a higher risk.
 
But a study published recently in PLoS One suggests that using race as a stand in for truly personalized genetic information may not work, especially in the most diverse cities (like New York and Los Angeles) that attract immigrants from around the world.

There’s a lot of genetic variability among races. And the genetic risk profiles for many people with mixed ancestry don’t fit neatly into any category…

Read the entire article here.

White persons and Malayans are forbidden to intermarry and both are forbidden to marry Negroes or persons of Negro descent to the third generation. The statutory mode of expression to cover persons of mixed white and Negro blood is an awkward one and makes doubtful just what proportion of Negro blood will disqualify one from marrying a pure white person or Malayan. It is suggested that if the person in question has some non-Negro blood and that if all of his parents and grand-parents also had some, he is eligible for purposes of the statute, even though he is predominantly Negro.

John S. Strahorn Jr., “Void and Voidable Marriages in Maryland and Their Annulment,” Maryland Law Review, Volume 2, Issue 3 (1938): 231.

Slooooooow Sales for BiDil^®

Biopolitical Times: The weblog of the Center for Genetics and Society
2006-10-18

Osagie K. Obasogie, Associate Professor of Law
University of California, San Francisco
Also: Senior Fellow
Center for Genetics and Society

Today’s Wall Street Journal reports that sales for BiDil^®—the first drug to receive FDAapproval to treat a specific race—are unexpectedly slow. Marketed as treating heart failure in African-Americans, BiDil^® was expected to generate $130 million in sales this year; thus far, only a little over $5 million has come in. Estimates show that only 1% of the 750,000 Blacks suffering from heart failure are using it.

There’s no shortage of explanations for why Black people are about as unlikely to take BiDil^® as they are to name a newborn child Katrina…

…But, perhaps there’s another explanation that the Wall Street wing tips are missing: a sense of history.

During a conference I attended earlier this year on BiDil^® and race specific medicines, an older Black woman in the audience stood up and said “If I were sick and somebody told me that they had a drug just for Black people to help me, I’d say to them: give me what the white people are taking.”…

Read the entire article here.

The Biopolitics of Mixing: Thai Multiracialities and Haunted Ascendancies

Ashgate Publishing
October 2012
198 pages
234 x 156 mm
Hardback ISBN: 978-0-7546-7680-5
ebook ISBN 978-1-4094-2502-1

Jinthana Haritaworn, Assistant Professor in Gender, Race and Environment at the Faculty of Environmental Studies
York University, Canada

Debates over who belongs in Europe and who doesn’t increasingly speak the language of mixing, but how are the figures commonly described as ‘mixed’ actually embodied? The Biopolitics of Mixing invites us to reckon with the spectres of pathologization past and present, placing the celebration of mixing beside moral panics over terrorism and trafficking and a post-race multiculturalism that elevates some as privileged members of the neoliberal community, whilst ghosting others from it. Drawing on a broad archive including rich qualitative interviews conducted in Britain and Germany, media and policy debates, popular culture, race-based research and queer-of-colour theories, this book imagines into being communities in which people and places normally kept separate can coexist in the same reality.

As such, it will appeal to scholars across a range of sociological and cultural studies, including critical race, ethnic and migration studies, transnational gender and queer studies, German and European studies, Thai and Southeast Asian studies, and studies of affect, performativity, biopolitics and necropolitics. It should be read by all those interested in thinking critically on the intersections of race, class, gender, sexuality and disability.

Contents

• Introduction: haunted origins
• Where are you from?
• From monster to fashion model: regenerating racialized bodies
• Is it better to be mixed race?
• Hybrid nations, mixed feelings: from marginal man to Obama
• Exceptional cities, exceptional citizens: metronormativity and mimeticism
• Reckoning with prostitutes: performing Thai femininity
• Conclusion: where do we want to go?
• Bibliography
• Index

Ian Thomson: Jamaica was modern before Britain

The Independent
London, England
2012-10-04

Miguel Cullen

To mark Black History Month the author of “Dead Yard: Tales of Modern Jamaica” talks to Miguel Cullen about the ways Jamaica is punching above its weight

Jamaica is a country that exceeds its limitations. For example India’s GDP is 180 times that of the West Indian country and Jamaica could fit inside it 300 times. Yet Jamaica won twice as many medals at the London Olympics, 12 to India’s six.

Musically it shines beyond its scope too: between the mid-1950s and 2000 Jamaica had produced one new music recording per 1,000 people each year – making it per capita the world’s most prolific generator of recorded music.

Jamaican culture has long been fashionable and on Google Trends, a means of measuring how highly words feature in the search engine. In the list of most-searched countries “Jamaica” comes a tight second to “Russia,” a country so big it makes Jamaica look like a minnow.

In view of Jamaica’s small financial and physical scale, it’s logical to think of it as a statistical freak of nature, an anomaly, to have such a broad world standing. How could such a tiny island, which is only this year celebrating 50 years of independence from the UK, compete with superpowers like India and Russia?

It was with this question in mind that, on the eve of Black History Month in the UK, I visited the London home of Ian Thomson, the author of the hugely successful (and controversial) Dead Yard: Tales of Modern Jamaica…

…The book won the Royal Society of Literature’s Ondaatje Prize, and the Dolman Travel Book of the Year. It combines serpentine, fragile descriptions of Jamaica’s natural beauty with an unafraid look at the horrors of Jamaican violence, in a way that is intransigent and unique.

“Jamaica was modern before Britain was,” Thomson tells me, sitting in his study overlooking the greenery of Alexandra Park. “What fascinated me about these Caribbean countries was that for me they’re the first modern societies – they were the first countries to have intermingling, mixed race people, across the colour bar.”

“When Jamaicans came to Britain in the 1950s and 1960s, they were often very surprised by the conservative reactions to some of them being mixed race – mixed racing had been going on for centuries in the Caribbean. So in a sense you could say that although Jamaica is in some ways parochial, in other ways it’s incredibly forward-thinking.”…

Read the entire article here.

Portuguese and Luso-Asian Legacies in Southeast Asia, 1511-2011, Volume 1: The Making of the Luso-Asian World: Intricacies of Engagement

Institute of Southeast Asian Studies
2011
323 pages
Soft cover ISBN: 978-981-4345-25-5
See Volume 1 here.

Edited by:

Laura Jarnagin, Visiting Professorial Fellow
Institute of Southeast Asian Studies in Singapore
also Associate Professor Emerita in the Division of Liberal Arts and International Studies at Colorado School of Mines (Golden, Colorado)

“In 1511, a Portuguese expedition under the command of Afonso de Albuquerque arrived on the shores of Malacca, taking control of the prosperous Malayan port-city after a swift military campaign. Portugal, a peripheral but then technologically advanced country in southwestern Europe since the latter fifteenth century, had been in the process of establishing solid outposts all along Asia’s litoral in order to participate in the most active and profitable maritime trading routes of the day. As it turned out, the Portuguese presence and influence in the Malayan Peninsula and elsewhere in continental and insular Asia expanded far beyond the sphere of commerce and extended over time well into the twenty-first century.

Five hundred years later, a conference held in Singapore brought together a large group of scholars from widely different national, academic and disciplinary contexts, to analyse and discuss the intricate consequences of Portuguese interactions in Asia over the longue dure. The result of these discussions is a stimulating set of case studies that, as a rule, combine original archival and/or field research with innovative historiographical perspectives. Luso-Asian communities, real and imagined, and Luso-Asian heritage, material and symbolic, are studied with depth and insight. The range of thematic, chronological and geographic areas covered in these proceedings is truly remarkable, showing not only the extraordinary relevance of revisiting Luso-Asian interactions in the longer term, but also the surprising dynamism within an area of studies which seemed on the verge of exhaustion. After all, archives from all over the world, from Rio de Janeiro to London, from Lisbon to Rome, and from Goa to Macao, might still hold some secrets on the subject of Luso-Asian relations, when duly explored by resourceful scholars.”

—Rui M. Loureiro
Centro de Historia de Alem-Mar, Lisbon

“This two-volume set pulls together several interdisciplinary studies historicizing Portuguese ‘legacies’ across Asia over a period of approximately five centuries (ca. 1511-2011). It is especially recommended to readers interested in the broader aspects of the early European presence in Asia, and specifically on questions of politics, colonial administration, commerce, societal interaction, integration, identity, hybridity, religion and language.”

—Associate Professor Peter Borschberg
Department of History, National University of Singapore

Table of Contents

• Preliminary pages
• PART I: ADAPTATIONS AND TRANSITIONS IN THE SOUTH AND SOUTHEAST ASIAN THEATRES, SIXTEENTH THROUGH EIGHTEENTH CENTURIES
  • 1. Supplying Simples for the Royal Hospital: An Indo-Portuguese Medicinal Garden in Goa (1520-1830), by Timothy D. Walker 
  • 2. Malacca in the Era of Viceroy Linhares (1629-35), by Anthony Disney
  • 3. From Meliapor to Mylapore, 1662-1749: The Portuguese Presence in Sao Tome between the Qut.b Shahi Conquest and Its Incorporation into British Madras, by Paolo Aranha
  • 4. Eighteenth-Century Diplomatic Relations between Portuguese Macao and Ayutthaya: The 1721 Debt Repayment Embassy from Macao, by Stefan Halikowski Smith
  • 5. Continuities in Bengal’s Contact with the Portuguese and Its Legacy: A Community’s Future Entangled with the Past, by Ujjayan Bhattacharya
• PART II: DISPERSION, MOBILITY AND DEMOGRAPHY FROM THE SIXTEENTH INTO THE TWENTY-FIRST CENTURIES
  • 6. The Luso-Asians and Other Eurasians: Their Domestic and Diasporic Identities, by John Byrne
  • 7. The Population of the Portuguese Estado da India, 1750-1820: Sources and Demographic Trends, by Paulo Teodoro de Matos
  • 8. Flying with the Papagaio Verde (Green Parrot): An Indo-Portuguese Folkloric Motif in South and Southeast Asia, by K. David Jackson
• PART III: MIXED LEGACIES: THE PORTUGUESE AND LUSO-ASIANS IN THE TWENTIETH AND TWENTY-FIRST CENTURIES
  • 9. Portuguese Communities in East and Southeast Asia during the Japanese Occupation, by Felicia Yap
  • 10. Indo-Portuguese Literature and the Goa of Its Writers, by Everton V. Machado
  • 11. Binding Ties of Miscegenation and Identity: The Narratives of Henrique Senna Fernandes (Macao) and Rex Shelley (Singapore), by Isabel Maria da Costa Morais
  • 12. Portuguese Past, Still Imperfect: Revisiting Asia in Luso-Diasporic Writing, by Christopher Larkosh
• Bibliography
• Index

See Volume 1 here.