Pharmacogenomics and the Biology of Race

Posted in Articles, Health/Medicine/Genetics, Media Archive, United States on 2015-01-08 02:36Z by Steven

Pharmacogenomics and the Biology of Race

Myles Jackson, Albert Gallatin Research Excellence Professor of the History of Science
New York University

The Huffington Post
2015-01-05

The numerous and impassioned responses to Nicholas Wade’s recently published Troublesome Inheritance: Genes, Race and Human History have once again reminded us of the complexity, ambiguity and perils of writing about the biology of race. In the US one is reminded of the collective sins of our past, including the eugenics movement of the early twentieth century, whereby a disproportionate percentage of people of color and those from lower socio-economic classes were sterilized, and the Tuskegee Study conducted between 1932 and 1972 in which 600 African-American sharecroppers in rural Alabama were purposely not treated for syphilis in order to ascertain information on the long-term effects of the disease. More recently, debates about the biology of race have raged among certain academic circles. While biologists will tell you that humans (other than identical twins, triplets, etc.) do differ from one another genetically — i.e. at the level of the DNA, they will also admit that the difference is rather small. And many (but certainly not all) are loath to label populations, which share the same genetic alleles (or different versions of a gene) as “races.” It turns out there are numerous ways in which one can understand human diversity, including geographic ancestry or responses to environmental selection factors. Sickle cell anemia is a case in point. Identified over a century ago, it was originally thought to be limited to “the Negro race.” As time went on, people from parts of Italy, Greece, Iran, India, and in other diverse locations were identified with the disease…

So why then is race the privileged category used by biomedical researchers in understanding human diversity? There are four sets of institutions that have used race as the primary signify of difference, albeit for very different reasons, the National Institutes of Health (NIH), the Food and Drug Administration (FDA), Big Pharma, and personal genomics companies…

…Big Pharma, while initially protesting what it saw as the unwarranted meddling of the government in the affairs of private companies, eventually embraced the move. They quickly realized that race creates markets, as Dorothy Roberts has argued in Fatal Invention (New Press, 2011). In 1996 the US became the second nation (after New Zealand) to permit direct-to-consumer advertising; Big Pharma began to market some of their drugs as race-based, including BiDil, used to treat African Americans with a history of heart attacks and Amaryl, which is used to treat type 2 diabetes in Mexican Americans. Many biomedical researchers have challenged the claims that these medications are more efficacious in one race than in the others…

Read the entire article here.

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Dorothy Roberts, “Fatal Invention: The New Biopolitics of Race.”

Posted in Health/Medicine/Genetics, Media Archive, Politics/Public Policy, Videos on 2014-11-28 23:08Z by Steven

Dorothy Roberts, “Fatal Invention: The New Biopolitics of Race.”

McMaster University
Hamilton, Ontario, L8S4L9, Canada
2014-10-23

Public Lecture: Dorothy Roberts, George A. Weiss University Professor of Law and Sociology at UPenn, came to McMaster University on October 23, 2014 to give a lecture titled “Fatal Invention: The New Biopolitics of Race.”

In her talk, Roberts examined the myth of the biological concept of race – revived by purportedly cutting-edge science, race-specific drugs, genetic testing, and DNA databases – continues to undermine a just society and promote inequality in a supposedly “post-racial” era.

Presented by the Bourns Lectureship in Bioethics and the McMaster Centre for Scholarship in the Public Interest.

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Q&A with Dorothy Roberts

Posted in Articles, Autobiography, Health/Medicine/Genetics, Interviews, Law, Media Archive, Social Science, United States, Women on 2014-11-17 00:32Z by Steven

Q&A with Dorothy Roberts

Penn Current: News, ideas and conversations from the University of Pennsylvania
2014-10-16

Greg Johnson, Managing Editor

When Dorothy Roberts was 3 months old, she moved with her parents from Chicago to Liberia, where her mother, Iris, had worked as a young woman after leaving Jamaica.

It was the first of Dorothy’s many trips abroad, and one during which her father, Robert, took a bunch of photographs and filmed home movies with his 16-millimeter camera. The Roberts family moved back to Chicago when Dorothy was 2, and she can recall weekly screenings of the 16-milimeter reels from Liberia in he living room.

“I had a very strong interest in learning about other parts of the world from when I was very little,” says Roberts, the 14th Penn Integrates Knowledge Professor. “My whole childhood revolved around learning about other parts of the world and engaging with people from around the world.”

Robert was an anthropologist and Iris was working on her Ph.D. in anthropology when Dorothy was born. They raised their daughters as citizens of the world in a home filled with a wealth of books and ethnographies about different cultures, places, and people. The Roberts home stayed connected with the international community, hosting foreign-exchange students and living overseas.

Five-year-old Dorothy had already decided she was going to be an anthropologist—as her parents expected—and would sneak into her father’s office and spend hours reading his books. The family spent two years in Egypt when she was a teenager, reinforcing her status as a global citizen.

Twenty-one-year-old Dorothy, after finishing her undergraduate studies at Yale, including a year in South America, decided she wanted to be a lawyer, and enrolled at Harvard Law School.

“I got a law degree and went into legal practice because I thought that was the best tool for doing social justice work,” says Roberts, who has joint appointments in the Departments of Africana Studies and Sociology in the School of Arts & Sciences and Penn Law School. Her work focuses on gender, bioethics, health, and social justice issues, specifically those that affect the lives of children, women, and African Americans.

Roberts began her legal career with one of the icons of the Civil Rights Movement, Judge Constance Baker Motley, for whom she clerked in the early 1980s. After practicing law in the private sector, she started her teaching career in 1988 at Rutgers University School of Law-Newark, an institution known for its history of social justice advocacy. She was a professor at Northwestern School of Law before joining Penn in 2012.

The Current sat down with Roberts in Penn Law’s Golkin Hall for a conversation about her globetrotting, her influential parents, racism in the child welfare system, the degradation of black bodies, the resurgence of race in science, and controversial decisions by the United States Supreme Court

…Q.Your most recent book, ‘Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century,’ examines the resurgence of biological concepts of race in genomic science and biotechnologies. What is it about?

A. Biological explanations have historically been a powerful way of convincing people that social inequality is natural and, therefore, does not require social change. To me, that is what the eugenics movement, which was prominent in the United States from the 1920s until World War II, was all about. Mainstream science in the United States promoted biological explanations for social inequality, claiming it resulted from differences in people’s inherited genetic traits. That basic ideology continues to this day in what is seen as cutting-edge and sophisticated scientific research. You can tie together all of my work from ‘Killing the Black Body’ to ‘Fatal Invention’ as uncovering the ways in which that basic philosophy—disguising social inequalities as biological ones—continues to fuel unjust social policies and legitimize very brutal practices against the most marginalized people in this country, blaming them for their own disadvantaged status. How can you blame the least powerful people for creating powerful systems of inequality in the United States? But the biological explanation for inequality deludes people into thinking that is possible—that it’s natural for black infants to die at two or three times the rate of white infants; it’s natural for black people to be incarcerated at many times the rate of white people; it’s natural for black children to have lower graduation rates than white children; it’s natural for black people to have a fraction of the wealth white people have. Americans who don’t want to explain these glaring inequities as stemming from institutionalized racism find comfort in explaining them as stemming from a natural order of human beings…

…What are you currently working on? I understand you are continuing a research project that was originally started by your father.

A. I’m working on a book using about 500 interviews of black/white couples that my father conducted in Chicago from 1937 to 1980. He was working on a book on interracial marriage my whole childhood but he never wrote it. My father was white and my mother was black. I want to take advantage of this extraordinary archive to study the relationship between the experiences and views of these couples and the intensifying challenge to the racial order that occurred during that period. How did they understand their own marriages in terms of changing race relations and politics in Chicago? I’m very interested in the role interracial marriage has played in perpetuating and contesting racial inequality.

While my father believed that interracial marriage could be a key strategy for overcoming racism, I neither glorify nor ignore its political significance. I am investigating interracial marriage from the perspective of black-white couples without assuming an inherently problematic or progressive role in the advancement of racial equality. And I’m very excited to explore what the interviews reveal.

Read the entire interview here.

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Race Medicine: Treating Health Inequities from Slavery to Genomics

Posted in Health/Medicine/Genetics, Live Events, Media Archive, Politics/Public Policy, Social Science, United States on 2014-10-31 19:21Z by Steven

Race Medicine: Treating Health Inequities from Slavery to Genomics

University of New England
Alfond Center for Health Sciences
Room 205
Biddeford, Maine
2014-11-03, 17:30 EST (Local Time)

Contact: David Livingstone Smith
Phone: (207) 602-2237

Annual David Hume Lecture on Human Nature

Dorothy Roberts, J.D., will trace the U.S. history of race medicine—the practice of treating disease according to race.

As Dr. Roberts will explain, race medicine has functioned to make health inequities and other forms of racial inequality seem natural and inevitable. This practice is no less troubling in today’s genomic age than at the time of its origins in slavery.

Roberts, an acclaimed scholar of race, gender and the law, is the 14th Penn Integrates Knowledge Professor at the University of Pennsylvania with a joint appointment in the Department of Sociology and the Law School where she also holds the inaugural Raymond Pace and Sadie Tanner Mosell Alexander chair…

For more information, click here.

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Dorothy Roberts Lecture: “Fatal Invention: The New Biopolitics of Race”

Posted in Canada, Health/Medicine/Genetics, Law, Live Events, Media Archive, Politics/Public Policy, Social Science on 2014-10-22 15:18Z by Steven

Dorothy Roberts Lecture: “Fatal Invention: The New Biopolitics of Race”

McMaster University
CIBC Hall, McMaster University Student Centre (MUSC 319)
280 Main Street West
Hamilton, Ontario, L8S4L9, Canada
2014-10-23, 19:00-21:00 EDT (Local Time)

The Bourns Lectureship in Bioethics and the McMaster Centre for Scholarship in the Public Interest present a lecture by Dorothy Roberts, George A. Weiss University Professor of Law and Sociology, Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights

Dorothy Roberts is the fourteenth Penn Integrates Knowledge Professor, George A. Weiss University Professor, and the inaugural Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights at the University of Pennsylvania, where she holds appointments in the Law School and Departments of Africana Studies and Sociology. An internationally recognized scholar, public intellectual, and social justice advocate, Roberts has written and lectured extensively on the interplay of gender, race, and class in legal issues and has been a leader in transforming public thinking and policy on reproductive health, child welfare, and bioethics.

She is the author of many award-winning texts including: Fatal Invention: How Science, Politics, and Big Business Re-Created Race in the Twenty-First Century (The New Press 2011), Shattered Bonds: The Color of Child Welfare (Basic Civitas Books 2002), and Killing the Black Body: Race, Reproduction, and the Meaning of Liberty (Random House 1997).

During her lecture at McMaster University, Roberts will examine how the myth of the biological concept of race – revived by purportedly cutting-edge science, race-specific drugs, genetic testing, and DNA databases – continues to undermine a just society and promote inequality in a supposedly “post-racial” era.

For more information, click here. View the poster here.

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Fatal Invention with Dorothy Roberts

Posted in Audio, Health/Medicine/Genetics, History, Interviews, Live Events, Media Archive, Politics/Public Policy, United States on 2014-07-30 20:49Z by Steven

Fatal Invention with Dorothy Roberts

Research at the National Archives and Beyond
BlogTalk Radio
Thursday, 2014-07-24, 21:00 EDT, (Friday, 2014-07-25, 01:00Z)

Bernice Bennett, Host

Dorothy Roberts, George A. Weiss University Professor of Law and Sociology; Raymond Pace and Sadie Tanner Mossell Alexander Professor of Civil Rights
University of Pennsylvania

Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century

Dorothy Roberts, an acclaimed scholar of race, gender and the law, joined the University of Pennsylvania as its 14th Penn Integrates Knowledge Professor with a joint appointment in the Department of Sociology and the Law School where she also holds the inaugural Raymond Pace and Sadie Tanner Mosell Alexander chair. Her pathbreaking work in law and public policy focuses on urgent contemporary issues in health, social justice, and bioethics, especially as they impact the lives of women, children and African-Americans. Her major books include Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century (New Press, 2011); Shattered Bonds: The Color of Child Welfare (Basic Books, 2002), and Killing the Black Body: Race, Reproduction, and the Meaning of Liberty (Pantheon, 1997). She is the author of more than 80 scholarly articles and book chapters, as well as a co-editor of six books on such topics as constitutional law and women and the law.

Popular History Internet Radio with BerniceBennett on BlogTalkRadio

Download the episode here.

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Approaching race as a social rather than biological construct

Posted in Articles, Health/Medicine/Genetics, Media Archive, United States on 2014-04-13 11:59Z by Steven

Approaching race as a social rather than biological construct

The Daily Pennsylvanian
Philadelphia, Pennsylvania
2014-04-08

Laura Anthony

The Program on Race, Science and Society will examine the role of race in scientific research at upcoming symposium

In 1851, University of Pennsylvania Perelman School of Medicine graduate Samuel Cartwright delivered a report to the Medical Association of Louisiana claiming that blacks’ health was improved by slavery.

He theorized that forced physical labor improved blacks’ inferior lung capacity, so slavery was actually a necessity to bettering their health.

Penn Law School professor Dorothy Roberts first heard this anecdote from a talk by Brown University professor Lundy Braun detailing the history of the spirometer, a medical device used to measure lung capacity.

Some spirometers historically, and even in modern medicine, adjust the measurements according to the race of the patient. Cartwright used the device to justify the need for continued slavery to protect blacks’ health. Braun’s presentation included a picture of a modern spirometer with a button labeled “race,” and through numerous conversations with medical students, Roberts has found that some medical students are still trained to use spirometers based on patients’ race.

For Roberts, this is a major problem. “My definition of race is that it is a political system to govern people based on invented biological demarcation, and it is not a natural division of human beings,” she said. “So it is much more plausible that inequities in health that fall along racial lines are caused by social determinants.”

Braun’s talk sparked an idea for a future project in the new program she developed at Penn this year called the Program on Race, Science and Society…

Read the entire article here.

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Penn symposium tackles race, science, and society

Posted in Articles, Health/Medicine/Genetics, Media Archive, United States on 2014-04-06 04:26Z by Steven

Penn symposium tackles race, science, and society

Penn Current: News Ideas and conversations from the University of Pennsylvania
University of Pennsylvania
2014-04-03

Katherine Unger Baillie

Is race a biological category? How does race figure into scientific research, clinical practice, and the development and use of biotechnology and pharmaceuticals? And what can we learn from historical investigations into race that will inform today’s scientific and medical inquiries?

These are among the complex questions that will be addressed by panels of experts during the April 11 symposium, “The Future of Race: Regression or Revolution?”

The event is being co-hosted by Penn’s new Program on Race, Science and Society (PRSS), which is based in the Center for Africana Studies, and the Penn Museum. The Center for Africana Studies is also co-sponsoring the symposium. The event will be held in the Museum’s Widener Lecture Hall from 9 a.m. to 3 p.m. The symposium is free and open to the public, though registration is required…

Read the entire article here.

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Fatal Invention: The New Biopolitics of Race and Gender – Dorothy Roberts

Posted in Health/Medicine/Genetics, Live Events, Media Archive, Politics/Public Policy, United States on 2014-03-07 17:09Z by Steven

Fatal Invention: The New Biopolitics of Race and Gender – Dorothy Roberts

University of California, Berkeley
Alumni House
Friday, 2014-03-07, 17:00-19:30 PST (Local Time)

Join us for a discussion with Prof. Dorothy Roberts, University of Pennsylvania Law School, author of Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century.  Lecture organized by the group, Politics of Biology & Race, a UC Center for New Racial Studies working group, and co-sponsored by the Center for Race & Gender and the Haas Center for a Fair and Inclusive Society.

Dorothy Roberts, an acclaimed scholar of race, gender and the law, joined the University of Pennsylvania as its 14th Penn Integrates Knowledge Professor with a joint appointment in the Department of Sociology and the Law School where she also holds the inaugural Raymond Pace and Sadie Tanner Mosell Alexander chair.

Her pathbreaking work in law and public policy focuses on urgent contemporary issues in health, social justice, and bioethics, especially as they impact the lives of women, children and African-Americans. Her major books include Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century (New Press, 2011); Shattered Bonds: The Color of Child Welfare (Basic Books, 2002), and Killing the Black Body: Race, Reproduction, and the Meaning of Liberty (Pantheon, 1997).

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On Race, Medicine, and Reproduction: An Interview with Dorothy Roberts

Posted in Articles, Health/Medicine/Genetics, Interviews, Politics/Public Policy, United States on 2014-02-20 07:59Z by Steven

On Race, Medicine, and Reproduction: An Interview with Dorothy Roberts

Bluestockings Magazine
Brown University
February 2014 (2014-02-14)

Dorothy Roberts is a scholar, professor, author and social justice advocate, and currently the 14th Penn Integrates Knowledge Professor at the University of Pennsylvania Law School. She has published a range of groundbreaking articles and books analyzing issues of law, race, gender, health and social inequality, including Killing the Black Body: Race, Reproduction, and the Meaning of Liberty (1997), Shattered Bonds: The Color of Child Welfare (2002) and, most recently Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century (2012). When she visited Brown University to discuss her latest work on race and health inequities, Bluestockings Magazine had the privilege of interviewing Prof. Roberts beforehand.

Sophia Seawell [Co-Editor-in-Chief]: To begin with, I was hoping that for those of us who aren’t able to come to your lecture if you could tell us what you’ll be speaking about and how it fits into what you’ve been working on lately.

Dorothy Roberts: I’m going to be talking about what I’m calling race medicine, which is the practice of treating diseases according to race both by using the notion that people of different races have different diseases and also that they experience common diseases differently. I argue that you can trace that practice in the United States from slavery, where the idea that Africans have different diseases was used to justify enslaving them, and also explained resistance to enslavement as a form of mental illness.

Race medicine has been used to treat social inequality as if it’s natural, and that’s a way to justify repression and to steer attention away from the need for social change. And so I show how those concepts and strategies that came out of slavery continue in contemporary medicine today, and how they’ve in fact been exacerbated by a new resurgence of the concept of biological races in genomic science, biomedical research, and medical practice.

So it’s a little bit of history, but I’m mostly looking at the way that treating disease as race-based and using that as a way to explain social inequality, especially racial inequality, has travelled across the centuries. We can’t believe that today, because we live in a liberal democracy and doctors say that they’re not racially biased, that we shouldn’t worry about it anymore.

SS: The first thing that comes to mind when you talk about race-based disease is high blood pressure in African Americans.

DR: I’ll use that example in my talk. I point out that it’s commonly thought among doctors and biomedical researchers that hypertension is higher in African Americans because of some innate difference—today it’s explained as a genetic difference—but actually these ideas originated before there was even knowledge of genetics, only now they’re cloaked in genetic terms.

I’ll mention a study conducted by a researcher named Richard Cooper who looked at a number of global studies, did a meta-analysis and discovered that in fact across theses studies people of African descent have a lower rate of hypertension than white people. It’s just in the United States that Blacks have a higher rates than whites; Nigerians have a lower rate than the average of people of European descent around the world. That’s pretty strong evidence, and there’s lots of other evidence as well that to the extent that African Americans have higher rates of blood pressure in the U.S., it’s nothing innate. There have been all sorts of biological theories—the salt hypothesis claimed that the Middle Passage weeded out certain genes and so those who survived it had a gene pool that predisposed them to hypertension. It doesn’t make sense! Because first of all, Jamaicans, whose ancestors also crossed the Atlantic, have a lower rate of hypertension than whites in the U.S.

SS: But we just won’t mention that!

DR: And I’ll talk about some other new fangled and ridiculous genetic explanations.

SS: I was also wondering, on a different note, about your experience in academia as a woman of color—specifically, since you do so much writing on race, medicine and science, if your work has ever been criticized because it’s “not objective” because it discusses race, or that you’re trying to “read race” into things.

DR: I’ve certainly gotten that response—pretty frequently in audiences when I talk about my most recent book, Fatal Invention, and especially if I’m talking to a group of physicians or people who are doing biomedical research. With genetic counselors I’ve also gotten a very defensive response. People feel you’re accusing them personally of racism and they want to defend their use of race in their practice and in their research. I’ve found that there’s this desire to hold on to biological racial concepts that is very disturbing to me. There’s a lot of resistance out there.

I’ve also spoken to very receptive audiences, and audiences that weren’t aware of this resurgence of concepts of biological concepts of race in science—what I call a new racial science—and many are very grateful to hear this information; they’re alarmed, but happy to hear about it.

Others believe that race is a political category if not a biological category, and that includes many scientists who understand that. So I’ve also been welcomed by some for my book, but there still is this resistance I’ve met and often the argument is “well, you just don’t understand the science.” But the thing is I’ve read many of these articles that claim to show that there are race-based genetic differences or that racial differences in health can be explained genetically and there’s so many flaws in them. Just simple flaws, like not defining what the scientist means by race…

SS: It’s just understood to be a natural category.

DR: They just use the term! They don’t explain how they decided who among their research subjects gets grouped in which race. Most of them use self-identification or come up with some made-up, invented way of determination… there are just so many flaws. They often control for just one socioeconomic variable and if they continue to see that race has an effect they leap to the conclusion that it must be genetic—which is also bad research, bad science. But the basic flaw is that they’re using a social category as if it was a biological category or a genetic category, and it isn’t. So the very basis of their hypothesis that genes cause health inequities, for example, is flawed. And then the methods of flawed on top of that…

Read the entire interview here.

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