Mixed Race Studies

Pharmacogenomics, human genetic diversity and the incorporation and rejection of color/race in Brazil

BioSocieties
March 2015, Volume 10, Issue 1
pages 48–69
DOI: 10.1057/biosoc.2014.21

Ricardo Ventura Santos
Escola Nacional de Saúde Pública/ FIOCRUZ & Museu Nacional/UFRJ, Rio de Janeiro, Brazil

Gláucia Oliveira da Silva
Universidade Federal Fluminense, Niterói, Brazil

Sahra Gibbon, Post-Doctoral Research Fellow
University College, London, United Kingdom

Public funding for research on the action of drugs in countries like the United States requires that racial classification of research subjects should be considered when defining the composition of the samples as well as in data analysis, sometimes resulting in interpretations that Whites and Blacks differ in their pharmacogenetic profiles. In Brazil, pharmacogenomic results have led to very different interpretations when compared with those obtained in the United States. This is explained as deriving from the genomic heterogeneity of the Brazilian population. This article argues that in the evolving field of pharmacogenomics research in Brazil there is simultaneously both an incorporation and rejection of the US informed race-genes paradigm. We suggest that this must be understood in relation to continuities with national and transnational history of genetic research in Brazil, a differently situated politics of Brazilian public health and the ongoing valorization of miscegenation or race mixture by Brazilian geneticists as a resource for transnational genetic research. Our data derive from anthropological investigation conducted in INCA (Brazilian National Cancer Institute), in Rio de Janeiro, with a focus on the drug warfarin. The criticism of Brazilian scientists regarding the uses of racial categorization includes a revision of mathematical algorithms for drug dosage widely used in clinical procedures around the world. Our analysis reveals how the incorporation of ideas of racial purity and admixture, as it relates to the efficacy of drugs, touches on issues related to the possibility of application of pharmaceutical technologies on a global scale.

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Racial Identities, Genetic Ancestry, and Health in South America: Argentina, Brazil, Colombia, and Uruguay

Palgrave Macmillan
October 2011
272 pages
Includes: 10 pages of figures, 10 pages of tables
5.500 x 8.250 inches
ISBN: 978-0-230-11061-8, ISBN10: 0-230-11061-4

Edited by

Sahra Gibbon, Wellcome Trust Fellow
Department of Social Anthropology
University College London

Ricardo Ventura Santos, Professor of Biological Anthropology and Public Health
Oswaldo Cruz Foundation
also Associate professor of Anthropology
National Museum, Rio de Janeiro, Brazil

Mónica Sans, Associate Professor and Director of the Biological Anthropology Department
University de la Republic in Uruguay

This unique edited collection brings together biologists, geneticists, and social and biological anthropologists to examine the connections between genetics, identity, and health in South America. It addresses a wide range of theoretical issues raised by the rapid changes in the field of genetic sciences. Contributors come from Brazil, Colombia, Argentina, Uruguay, the UK, and the United States, providing a comparative cultural perspective for scholars, researchers, and students.

Table of Contents

• Preface; N.Redclift
• PART I: DOING AND DEFINING “BIO-CULTURAL” ANTHROPOLOGY AS APPLIED TO GENETICS
  • Anthropology, Race, and the Dilemmas of Identity in the Age of Genomics; R.Ventura Santos & M.Chor Maio
  • The Inexistence of Biology Verses the Existence of Social Races: Can Science Inform Society?; S.D.J.Pena & T.S.Birchal
  • Ethics/Bioethics and Anthropological Fieldwork; A.L.Caratini
• PART II: ADMIXTURE MAPPING AND GENOMICS IN SOUTH AMERICA AND BEYOND
  • Admixture Dynamics in Hispanics: A Shift in the Nuclear Genetic Ancestry of a South American Population Isolate; L.Ruiz
  • Pharmacogenetic Studies in the Brazilian Population; G.Suarez-Kurtz & S.D.J.Pena
  • Admixture Mapping and Genetic Technologies; B.Bertoni
  • The Significance of Sickle Cell Anemia within the Context of the Brazilian Government’s ‘Racial Policies’ (1995-2004); P.H.Fry
• PART III: GENETIC ADMIXTURE HISTORY, NATIONHOOD AND IDENTITY IN SOUTH AMERICA
  • Gene Admixture and Type of Marriage in a Sample of Buenos Aires Metropolitan Area; F.R.Carnese
  • Ethnic/Race Self-Adscription, Genetics, and National Identity in Uruguay; M.Sans
  • Forced Disappearance and Suppresion of Identity of Children in Argentina: Experiences after Genetic Identification; V.B.Penchaszadeh
  • Molecular Vignettes of the Columbian Nation: The Place of Race and Ethnicity in Networks of Biocapital; C.A.Barrigan
• Afterward/Commentaries; R.Rapp, T.Disotell, M.Montoya & P.Wade